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In response to the ongoing opioid overdose crisis, all 50 states and the District of Columbia have modified their laws to increase access to naloxone, the standard first-line treatment for opioid overdose. While these laws have been successful in increasing access to this lifesaving medication, few explicitly address the legality of distributing and administering naloxone that is past its expiration date. This fact sheet briefly discusses the efficacy of expired naloxone and examines whether Missouri law permits the distribution and administration of such naloxone.